Tired, Foggy, or Aging Too Fast? What You Need to Know About NAD+

We Tested the Top NAD+ options out there—Here’s What Really Works for Energy, Aging, and Cellular Repair

Anti-Aging Specialist, Dr. Michael Setareh reviews the top selling NAD+ Booster on the market.

As a doctor who’s spent years helping people feel their best, I’m always looking for safe, natural ways to slow aging and boost health.

One of the most exciting breakthroughs I’ve seen is something called NAD+.
It’s a molecule your body needs to:

✅ Create energy

✅ Repair DNA

✅ Keep skin firm

✅ Support your brain and memory

But as we get older, NAD+ levels drop. And that’s when we start feeling tired, forgetful, and just not like ourselves.

So, it makes sense to take something that helps bring those NAD+ levels back up. But with so many NAD+ boosters on the market, how do you know which one works?

That’s What My Team and I Set Out to Find

We reviewed and tested the most popular NAD+ supplements. We looked at ingredients, safety, and most of all—results.

Here’s what we found. These are the 6 most important things to look for in a high-quality NAD+ booster:

 

  1. Proven Results in Human Studies – Don’t settle for guesswork. Choose a product that’s been tested on real people, not just animals or cells in a lab. It should show clear improvements in energy, aging, and cell health.

  2. Activates Sirtuin Proteins (Your Body’s “Youth Switch”) – Sirtuins help your body repair damage, calm inflammation, and slow down aging. A good NAD+ booster will activate these proteins so your cells work better—and longer.

  3. Multi-Pathway ApproachRaising NAD+ isn’t enough. The best products also help fight inflammation, oxidative stress, and support cell repair. Look for a supplement that works from more than one angle.

  4. Clean, Transparent Ingredients – You should know exactly what you’re putting into your body. High-quality NAD+ products list every ingredient and how much of it is included.

  5. Easy to Absorb and Gentle on Your Body – Your body has to use the supplement for it to work. So it needs ingredients that absorb well and don’t upset your stomach or cause side effects. No fillers. No fluff. Just real, usable support.

  6. 100% Safety – A good NAD+ booster should be safe to take and easy on your body. Look for products that are tested for safety and made without extra fillers or harmful additives. You want something clean, pure, and trusted.

💚 If You Struggle With:


  • Feeling Tired or Drained

  • Brain fog or low focus

  • Aging skin or slow recovery

  • Stiff joints or body aches

  • Inflammation or poor sleep

NAD3 may be the simple, science-backed solution you've been waiting for.

About The Doctor


Dr. Michael Setareh

Expert in Integrative Medicine & Longevity

Dr. Michael Setareh is a renowned specialist in Integrative Medicine and Longevity, with a focus on cutting-edge anti-aging research & treatment protocols. Through years of experience in his real-world medical practice with innovative treatment methods, Dr. Setareh has helped countless patients unlock their full potential through advanced health strategies. As our blog author, he provides readers with actionable insights, the latest research on aging, and practical tips for optimizing wellness. His goal is to inspire others to live healthier, more vibrant lives by embracing science-backed solutions.

Supplement Informant's Top Choice for 2025


NAD3 by High Performance Nutrition

Overall Rating: Excellent

Here Is My Top Choice for the #1 NAD+

🏆 #1 Pick: NAD3 by HPN

If you’re looking for a real, effective NAD+ supplements, NAD3 is my top recommendation.

As a doctor, I’ve tested many different options. NAD3 stood out the most—not just for how it raises NAD+ levels, but for how it helps your entire body feel younger, stronger, and more energized.

🔬 Why NAD3 Is Different

NAD3 supports your health in many important ways, all at once:

Boosts Energy Levels – Feel more awake and alert all day, without caffeine
Raises NAD+ in Just 24 Hours – Quickly supports your body at the cellular level
Improves Mental Clarity – Say goodbye to brain fog and stay sharp
Reduces Inflammation – Helps ease joint stiffness and body aches
Supports Healthy Aging – Activates “youth proteins” that repair & protect your cells
Enhances Immune Defense – Strengthens your body’s natural protection system
Speeds Up Recovery – Boosts stem cells to help you heal and feel your best
Promotes Heart Health – Lowers bad cholesterol and blood fats in just 12 weeks

🧪 Real Science. Real Results.

📉 In just 12 weeks, NAD3 was shown to lower LDL cholesterol and triglycerides
🧬 In just 3 days, it raised stem cell activity—helping the body repair and heal faster
⚡️ Users also reported more energy, better focus, and improved sleep

✅ What Makes NAD3 the Best? ❌ CONS

Works in multiple ways—not just boosting NAD+
Backed by 4 human clinical trials
5x more effective than NR or NMN
All-natural, no fillers, no fluff
Fast-acting results—feel a difference in just weeks

  • Sells out quickly due to high demand.
  • Only available online.

2. TRU Niagen

TRU Niagen is a well-known NAD+ booster that uses NR (nicotinamide riboside) as its primary ingredient. While NR has been shown to boost NAD+ levels, it lacks the multi-pathway approach seen in more advanced products like NAD3.

MSRP: $49
NO KNOWN PROMOTION AVALABLE

PROS CONS
  • Backed by multiple studies showing increases in NAD+ levels.
  • Simple, straightforward formula.
  • Relies solely on NR, which may not work as well for everyone.
  • Does not address inflammation or Sirtuin activation.
  • Limited clinical evidence on long-term anti-aging benefits.

3. Rho Liposomal NAD+ Booster

Rho Liposomal NAD+ Booster uses liposomal delivery to improve the absorption of NAD+ precursors. While this approach enhances bioavailability, it falls short in addressing multiple pathways like Sirtuin activation and inflammation reduction.

MSRP: $55.95
NO KNOWN PROMOTION AVALABLE

PROS CONS
  • Liposomal delivery may improve absorption.
  • Some prefer a liquid versus a capsule but taste might be an issue.
  • Contains synthetic NAD, which has shown limited uptake potential when consumed orally
  • Focuses primarily on absorption without additional cellular health benefits.
  • Limited clinical data on its efficacy.

4. Reus Research NAD+ Booster

Reus Research offers a basic NAD+ booster formula with NR. While it’s a decent option, it lacks the comprehensive approach of NAD3 and has minimal clinical data to support its claims.

MSRP: $59.99
NO KNOWN PROMOTION AVALABLE

PROS CONS
  • Multi-Ingredient Formula.
  • Affordable.
  • Limited clinical data.
  • Contains the unproven and untested Hydrogen Malate form of NR
  • Under-dosed secondary ingredients make the formula unlikely to provide benefits beyond NAD+ production.

Conclusion

After testing the most popular NAD+ boosters, one stood out above the rest: NAD3.
It’s not just about raising NAD+ levels. NAD3 helps your whole body feel better. It gives you more energy, helps your brain stay sharp, supports your heart, and slows signs of aging—all at the same time.

Most products only do one thing. NAD3 does many. That’s why it’s the best choice if you want real, full-body results.

Other brands like TRU Niagen and Elysium Basis may help a little, but they don’t do as much as NAD3. If you're ready to take better care of your body and age in a healthier way, NAD3 is the clear winner.

 

About Dr. Micheal Setareh

Dr. Michael Setareh is a renowned specialist in Integrative Medicine and Longevity, with a focus on cutting-edge anti-aging research & treatment protocols. Through years of experience in his real-world medical practice with innovative treatment methods, Dr. Setareh has helped countless patients unlock their full potential through advanced health strategies. As our blog author, he provides readers with actionable insights, the latest research on aging, and practical tips for optimizing wellness. His goal is to inspire others to live healthier, more vibrant lives by embracing science-backed solutions.

 

Tired, Foggy, or Aging Too Fast? What You Need to Know About NAD+

Dr. Michael Setareh & Testing Team | December 11, 2024 | Views: 453760

We Tested the Top NAD+ options out there—Here’s What Really Works for Energy, Aging, and Cellular Repair

💚 If You Struggle With:

✅ Feeling Tired or Drained

Aging skin

✅ Slow recovery

Inflammation

Brain fog or low focus

Stiff joints or body aches

Stubborn Weight Gain

Poor Sleep

Anti-Aging Specialist, Dr. Michael Setareh reviews the top selling NAD+ Booster on the market.

As a doctor who’s spent years helping people feel their best, I’m always looking for safe, natural ways to slow aging and boost health.

One of the most exciting breakthroughs I’ve seen is something called NAD+.
It’s a molecule your body needs to:

✅ Create energy

✅ Repair DNA

✅ Keep skin firm

✅ Support your brain and memory

But as we get older, NAD+ levels drop. And that’s when we start feeling tired, forgetful, and just not like ourselves.

So, it makes sense to take something that helps bring those NAD+ levels back up. But with so many NAD+ boosters on the market, how do you know which one works?

That’s What My Team and I Set Out to Find

We reviewed and tested the most popular NAD+ supplements. We looked at ingredients, safety, and most of all—results.

Here’s what we found. These are the 6 most important things to look for in a high-quality NAD+ booster:

  1. Proven Results in Human Studies – Don’t settle for guesswork. Choose a product that’s been tested on real people, not just animals or cells in a lab. It should show clear improvements in energy, aging, and cell health.

  2. Activates Sirtuin Proteins (Your Body’s “Youth Switch”) – Sirtuins help your body repair damage, calm inflammation, and slow down aging. A good NAD+ booster will activate these proteins so your cells work better—and longer.

  3. Multi-Pathway ApproachRaising NAD+ isn’t enough. The best products also help fight inflammation, oxidative stress, and support cell repair. Look for a supplement that works from more than one angle.

  4. Clean, Transparent Ingredients – You should know exactly what you’re putting into your body. High-quality NAD+ products list every ingredient and how much of it is included.

  5. Easy to Absorb and Gentle on Your Body – Your body has to use the supplement for it to work. So it needs ingredients that absorb well and don’t upset your stomach or cause side effects. No fillers. No fluff. Just real, usable support.

  6. 100% Safety – A good NAD+ booster should be safe to take and easy on your body. Look for products that are tested for safety and made without extra fillers or harmful additives. You want something clean, pure, and trusted.

Here Is My Top Choice for the #1 NAD+

🏆 #1 Pick: NAD3 by HPN

If you’re looking for a real, effective NAD+ supplements, NAD3 is my top recommendation.

As a doctor, I’ve tested many different options. NAD3 stood out the most—not just for how it raises NAD+ levels, but for how it helps your entire body feel younger, stronger, and more energized.

🔬 Why NAD3 Is Different

NAD3 supports your health in many important ways, all at once:

Boosts Energy Levels – Feel more awake and alert all day, without caffeine
Raises NAD+ in Just 24 Hours – Quickly supports your body at the cellular level
Improves Mental Clarity – Say goodbye to brain fog and stay sharp
Reduces Inflammation – Helps ease joint stiffness and body aches
Supports Healthy Aging – Activates “youth proteins” that repair & protect your cells
Enhances Immune Defense – Strengthens your body’s natural protection system
Speeds Up Recovery – Boosts stem cells to help you heal and feel your best
Promotes Heart Health – Lowers bad cholesterol and blood fats in just 12 weeks

🧪 Real Science. Real Results.

📉 In just 12 weeks, NAD3 was shown to lower LDL cholesterol and triglycerides
🧬 In just 3 days, it raised stem cell activity—helping the body repair and heal faster
⚡️ Users also reported more energy, better focus, and improved sleep

 

✅ What Makes NAD3 the Best?

  • Multi-pathway approach for comprehensive cellular health.
  • Backed by 4 human clinical trials.
  • 5x more effective than traditional NAD+ boosters like NR and NMN.
  • Safe, all-natural formula with no fillers.
  • Noticeable results within weeks.

 

❌ CONS

  • Sells out quickly due to high demand.
  • Only available online.

2. TRU Niagen

TRU Niagen is a well-known NAD+ booster that uses NR (nicotinamide riboside) as its primary ingredient. While NR has been shown to boost NAD+ levels, it lacks the multi-pathway approach seen in more advanced products like NAD3.

MSRP: $49
NO KNOWN PROMOTION AVALABLE

 

PROS:

  • Backed by multiple studies showing increases in NAD+ levels.
  • Simple, straightforward formula.

CONS:

  • Relies solely on NR, which may not work as well for everyone.
  • Does not address inflammation or Sirtuin activation.
  • Limited clinical evidence on long-term anti-aging benefits.

3. Rho Liposomal NAD+ Booster

Rho Liposomal NAD+ Booster uses liposomal delivery to improve the absorption of NAD+ precursors. While this approach enhances bioavailability, it falls short in addressing multiple pathways like Sirtuin activation and inflammation reduction.

MSRP: $55.95
NO KNOWN PROMOTION AVALABLE

PROS:

  • Liposomal delivery may improve absorption.
  • Some prefer a liquid versus a capsule but taste might be an issue.

CONS:

  • Contains synthetic NAD, which has shown limited uptake potential when consumed orally
  • Focuses primarily on absorption without additional cellular health benefits.
  • Limited clinical data on its efficacy.

4. Reus Research NAD+ Booster

Reus Research offers a basic NAD+ booster formula with NR. While it’s a decent option, it lacks the comprehensive approach of NAD3 and has minimal clinical data to support its claims.

MSRP: $59.99
NO KNOWN PROMOTION AVALABLE

PROS:

  • Multi-Ingredient Formula.
  • Affordable.

CONS:

  • Limited clinical data.
  • Contains the unproven and untested Hydrogen Malate form of NR
  • Under-dosed secondary ingredients make the formula unlikely to provide benefits beyond NAD+ production.

Conclusion

After testing the most popular NAD+ boosters, one stood out above the rest: NAD3.
It’s not just about raising NAD+ levels. NAD3 helps your whole body feel better. It gives you more energy, helps your brain stay sharp, supports your heart, and slows signs of aging—all at the same time.

Most products only do one thing. NAD3 does many. That’s why it’s the best choice if you want real, full-body results.

Other brands like TRU Niagen and Elysium Basis may help a little, but they don’t do as much as NAD3. If you're ready to take better care of your body and age in a healthier way, NAD3 is the clear winner.

 

About Dr. Micheal Setareh

Dr. Michael Setareh is a renowned specialist in Integrative Medicine and Longevity, with a focus on cutting-edge anti-aging research & treatment protocols. Through years of experience in his real-world medical practice with innovative treatment methods, Dr. Setareh has helped countless patients unlock their full potential through advanced health strategies. As our blog author, he provides readers with actionable insights, the latest research on aging, and practical tips for optimizing wellness. His goal is to inspire others to live healthier, more vibrant lives by embracing science-backed solutions.